Alot of things come into 'thought range', when you're lowering compression, by any means.
You need less cam. The flame travel is different, (again, depending on which way you lower compression.
I've always zero decked pistons, and tried/attempted to get every last spec of compression ratio out of any engine I"ve put together. Streetability has NEVER been one of my concerns, (but enough about me).
Anytime you lower compression, you lose HP/TQ. But, again, depending on how MUCH you lose would be the deciding factor. Again, getting back to HOW you lower the compression here is the gig.
It's kind of a strange question, (not flaming you by any means), but going backwards to how I think.
In either case, good luck on your engine build.
(love those AFR heads if you're still in the head purchasing gig)......