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I believe you can do it with a 4780 main body, but not sure about the 4781... according to the info I've seen the 850 (4781) has larger 1-3/4" throttle bores.

http://www.oldholden.com/possible/index.php/Holley_Information_Table1

I've done what you are proposing except with a 750 (4779) main body and it works great. But maybe as you said, all the parts will work together, and you'll just have a little less CFM than a normal 850?
 
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