Got a 289 running C-4 & 4;11 rear gears. At 65mph it's turning about 3000 rpm. Anything wrong with long trips at that kind of rpm? I know it will burn lots of gas. LOL
Some general advice for more than the original poster:
Hard to beat a 3.25 gear if you're going to travel at 65 mph very much at all. That's what I ran in the mustang while driving it back and forth to college 100 miles each way... and on 5 hour trips each way during the summers to Baltimore. Still had plenty of zip, and could actually keep up with traffic without making you cringe.
You can still keep a 4.11 for 'special occasions' as it can be really fun in town or if you want to go racing. A couple things to look out for in case you want to swap back and forth and/or not have to change driveshafts...
1. Make sure each rear is set up for the same spline axles. (28 vs 31 spline) It is probably 28.
2. The rear end YOKE. These came in four versions. Short and long length... and wide or narrow U-joint. They came in every variation... Short/wide. Short/narrow. Long/wide. Long/narrow. You'll want to have the same yoke for compatibility.
I've had my car since age 15, and I'm 52 now. It was my daily driver for YEARS. I've had more engines, transmissions and rear ends in the car than I care to count... especially rear ends in both 8" and 9". I've used the following ratios (pretty much all of them) on the street and strip, and really like the 3.25 for overall street use on street tires. 2.80, 3.00, 3.25, 3.40, 3.50, 3.55, 3.70, 3.89, 4.11, 4.30, 4.33, 4.57 and 4.86.
So my recommendation from real life experience is the 3.25 for a street engine built to shift at around 6000-6300 rpm with either a stick shift or mild converter and no overdrive. A more 'race' engine designed to be shifted at around 7k rpm and/or a 4k+ stall converter will gravitate more toward the steeper gear.
It's also my experience that Flowdisaster mufflers can sound cool, but don't flow all that well, and will drive you absolutely nuts with their droning.
Good Luck!