Just for perspective and comparison, I have a 66 custom 500 4 door and I'm running a 18x8.5 with 4.25 BS (-25 mm offset) wheel up front and 18x10 with ~4 1/8" bs (-35mm offset) rear. Front tires are 225/45 and rears are 255/45. I am running 2.5" lower than stock springs and have minimal clearances in rear between the tire and QP. Even less tolerances in the front in tight turns.
Those are fairly narrow tires for the wheel widths you're running, I'm setting up the '64 Country Sedan with the same wheel widths you're using but 245/50 fronts and 285/40 rears. I'm surprised to find the later cars have less clearance than the early tubs. -25mm is a fair bit of negative offset in front, any adverse effect on the steering?
I can't remember the exact offset I specced for the wheels, it's very slightly positive, I pulled the fronts in as close to the control arms as I could. There''s plenty of overall clearance to the fenders and frame except at the lip, I had the fender lip flared as much as I could for clearance without having to remove the side spear but it may still have some impact on on steering lock, and of course that car rubbed the tires on the sway bar even with G78-14s so I'll deal with that when I get to it. I think '64s have the lowest front fender openings of any of the early cars.
Out back it's tight but livable on the outside (there'd be lots more room if one wanted to cut up the fenderwell, which is well inboard of the sculpted outside sheetmetal of the car, but I don't), the bumpstop bracket on the inside's kinda in the way but it's coming off anyway...as you can tell it has little use with the rear suspension that's in the car:
The tires are not as close to the frame rails as they look in that pic:
Never mind all the rough edges on the brackets and crossmember, that will all get cleaned up when the finish welding's done, right now working on engine/trans mounts (and getting the '65 Mustang running, and a bunk bed for the daughter for Christmas...)
The biggest possible frame-clearance issue beyond the bumpstop bracket is that I may have to notch the outside of the frame rails ~1.5in for upper control arm clearance.